Air-water two-phase flow development in a vertical pipe has been investigated through service of experiments and simulations in this research. Differential Pressure Transducers (DPTs) and Wire Mesh sensors (WMSs) are used to monitor the two-phase flow in a vertical pipe of 67 mm inlet diameter and 7000 mm length. Computational Fluid Dynamic (CFD) is used to evaluate the experiments of the air-water flow in the vertical pipe using a volume of fluid (VOF) model. The operating conditions cover a range of inlet air superficial velocities from 0.05 to 5 m/s. The inlet water superficial velocity remains constant at 0.2m/s and 0.4 m/s for all experiments. The results show that the bubbly flow is noted at low superficial velocities of gas, slug flow is observed at the moderate flow rates of gas, while the churn flow pattern is observed at high rates of gas. There is no significant effect when the Usl changed from 0.2 m/s to 0.4 m/s on the vertical flow lines. Pressure drop is recorded and compared with the CFD simulations. The CFD results are over estimation compared with the experimental pressured drop with maximum absolute error of 21% at Usl of 0.2 m/s and 25% at Usl 0.4 m/s.