The mechanical properties of the interface between soil and structure have always been a hot topic in geotechnical engineering. In order to explore the interfacial shear characteristics of non-water reaction polymer and concrete, the effects of vertical stress and shear rate on shear strength and shear modulus of polymer concrete interface were studied based on monotonic direct shear test. The experimental results showed that: under the given vertical stress and shear rate, with the increase of shear displacement, the polymer concrete interface presented shear softening phenomenon. The shear rate had little effect on the interfacial shear strength, cohesion and friction angle, but had a significant impact on the interfacial shear modulus, and the shear modulus value decreased with the increase of shear rate, and the decrease amplitude was obvious; the vertical stress had a significant impact on the shear strength and shear modulus of polymer concrete interface, and the shear strength and shear modulus of polymer concrete interface changed with the increase of shear rate. The vertical stress increased continuously. At the same time, the hyperbolic constitutive model formula of polymer concrete interface was systematically deduced, and the validity of the model was preliminarily verified according to the relevant experimental results.