Betaine plant is one of the high-risk industries since it processes a dangerous, toxic, and flammable raw material called dimethylaminopropylamine (DMAPA) under high temperature and high-pressure operating conditions. This study analyses the risk impact of DMAPA in the chemical process area. This research was conducted at Betaine Plant Unilever Oleochemical Indonesia (UOI). Leaks occur in iso tank truck, unloading pump, storage tank, feed pump, and amidoamine reactor with wind direction as an independent variable like, west southwest (WSW), northeast (NE), and northwest (NW) where the potential dangers are jet fire, flash fire, pool fire, and gas dispersion. Consequence’s analysis is conducted with the ALOHA simulation, and worst scenario determination by using HAZOP, Risk Ranking Matrix, and f-N curve. Consequences analysis by utilizing ALOHA shows that the northwest wind direction is the most terrible wind direction with the damage about 16 facilities. The result of f-N curve, HAZOP, and Risk Ranking Matrix analysis show that the leaking in the amidoamine reactor is the worst-case scenario with the frequency of about 1000 years with a radius of around 42 meters and the fatality is approximated about 31 people. Within this research, it is also proposed 4 steps regarding emergency management for every scenario like mitigation through adding some safety instruments, planning and preparedness through the training and creation of an emergency response team, rescue through evacuation routes, and recovery through re-commissioning event.