The aim of the present study is to evaluate the ultraviolet (UV lamps, wavelength 365 nm, power 6 W) protective activity of Echinacea purpurea in mice skin model and compare its data with a commercial sunscreen agent. In these results, a phytopharmaceutical containing extract of Echinacea purpurea was investigated for its suggested immune stimulation potential. The photoprotective potential was evaluated by histopathological examination of the skin. Results showed that skin group irradiated with (UV lamps, wavelength 365 nm, power 6 W). showed highly a significant histopathological change, it showed skin necrosis and thickening of dermal collagen. The elevated serum pro-inflammatory cytokines, TNF-α, as well as PGE-2 were decreased in non or wounded mice with Echinacea purpurea and (UV lamps, wavelength 365 nm, power 6 W). The treatment with Echinacea purpurea protected skin tissues against UV damage by restoring histopathology changes.