The Venturi flow meter provides various measurement options in piped systems for liquids, gas, steam and slurries. Measuring fluid flow with a Venturi flow meter results in permanent pressure loss due to the friction on the walls of the meter, cone angles and geometry transition points. The ISO-5167 standard specifies the geometry and method of use for Venturi meters installed in a horizontal orientation for unidirectional flows with Reynolds numbers higher than 200,000. This research aims to investigate and compare the performance of a symmetrical Venturi meter with an ISO-5167 meter in terms of permanent pressure loss at upward inclination angles for flows with a Reynolds number of ≈34,000. The key findings from the research indicate that both symmetrical and ISO-5167 Venturi meters can be installed vertically to save room, and this does not increase the permanent pressure losses for single-phase incompressible isothermal low Reynolds number turbulent flows. Furthermore, the results indicate that the permanent pressure loss in a vertical orientation may decrease slightly, a trend particularly noticeable in the ISO-5167 Venturi meter.