The seismic effect created by blasting operations vibrates adjacent buildings and disturbs residents living in these buildings, often leading to disputes and complaints. In this paper, the vibration acceleration was calculated based on the measured blasting vibration velocity using the wavelet denoising-based four-point forward difference method. The infinite impulse response (IIR) digital filter was used to obtain the frequency weighting of acceleration, so as to calculate comfort assessment indexes such as vibration dose value (VDV), maximum weighted vibration severity (KBFmax and annoyance rate. Combined with the survey of engineering cases, comparative analysis was conducted on the indexes and standards that were suitable for the comfort assessment of blasting vibration. The results indicated that VDV, KBFmax, and annoyance rate indexes could all reflect the impact of blasting vibration on comfort to a certain extent, and that while the first two indexes could only be used for qualitative assessment, the annoyance rate index could be used for quantitative comfort assessment. In addition, by applying these assessment indexes for the comfort assessment of blasting vibration, preliminary control standards were provided.