Abstract : Outdoor space in any area especially in residential places is an important element that has a great impact on the human’s psychology, mental health and performance, as it can affect the heart rate and blood pressure. In addition, outdoor spaces are the most used spaces as they influence residents to interact with one another [1]. One of the most important factors that helps in the success of any outdoor space is its thermal comfort. Whereas, Human’s thermal comfort is defined as a state of mind that conveys satisfaction with one's surroundings, High temperatures and humidity can cause discomfort and, in some cases, heat stress which is a reduction in the body's ability to cool itself. While every country in any region in the world has its own climatic characteristics, Egypt’s climatic condition is hot and dry in summer and moderate in winters [13]. Moreover, high outdoor air temperatures and low relative humidity are common during the hot summer months in Egypt because of the intense sun radiation. As a result, discomfort and heat stress are more likely to occur which can also lead to urban heat island (UHI) phenomenon [15]. One of the aspects that can solute and helps in enhancing the thermal comfort in outdoor spaces is the building and planting design orientation and layout configuration taking in consideration the planting orientation including spacing, design and different species of planting [23]. Thus, this research aims to measure the impacts of layout configuration of buildings and investigate the effect of planting on the outdoor thermal comfort in the residential areas. The enhancement of the residential outdoor thermal comfort will be investigated and discussed. This is achieved by mixed qualitative and quantitative methodology approach. First, a literature review that will investigate a-climate, b-thermal comfort, c-layout configuration, d-planting design. Second, presenting and analyzing the case studies. Third, a simulation using Envi-met to study and compare the heat, light and air (thermal comfort) of the outdoor areas in different closed residential building clusters in Egypt as an example. By applying the different climate factors, in order to reach the best building orientation and outdoor layout configuration which obtains the best thermal comfort results. Finally, the research should end up with conclusions and recommendation for achieving the research aim.