Chalcones provide an easy way into many heterocyclic systems containing oxygen and nitrogen. As a result, an attempt is made to synthesis chalcones from 3-acetylpyridine by Claisen-Schmidt condensation with either aromatic or heteroaromatic aldehyde. To form (A1, A2, A3). The resulting chalcones after purification and characterization by physical and spectral methods have been successfully converted into pyrazole by reaction with hydrazine hydrate to form (A4,A5,A6). The synthesized test compounds were evaluated for various pharmacological activities such as antioxidant, anti-inflammatory, antibacterial activities. The results of the present investigation that compound (A6) has high antioxidant activity. These pharmacological activities included melting point, IR, 1H-NMR spectral studies.