Abstract : Interest in the topic of neighborhood change and transformation began around the twentieth century, to study the phenomenon of change and decay of neighborhoods. The main objective of this paper is to understand and analyze the manifestations, and dynamics of the morphology of areas with unique values in Cairo city and the different demographic, social, economic, political, and management forces guiding that transformation. The study analyzes the urban morphology of Heliopolis, Cairo including layout and land use, densities, heights, streets and transportation network, urban open space, and architectural heritage. Research methods include a field survey, photography, and official reports and documents verifying the neighbor's history. Results show that the most transformed elements of urban form are land use, Architecture and urban heritage, and Building heights and Densities, while urban policies/regulations, Economic/market as well as administration are the driving forces behind that transformation. This study helps urban planners and decision-makers to comprehend factors impacting the transformation and decay of our heritage neighborhoods.